City, who won 2-1 in Madrid in December, will look to build on their previous success, having been Champions League winners in 2023. Meanwhile, reigning champions Paris Saint-Germain will take on Chelsea, with the first leg at home for PSG.
Other notable fixtures include Newcastle United vs Barcelona, Liverpool vs Galatasaray, Arsenal vs Bayer Leverkusen, and Tottenham Hotspur vs Atletico Madrid. The first legs will take place on March 10 and 11, with the second legs a week later.
Here's a breakdown of the Champions League last 16 fixtures:
- *PSG vs Chelsea*: Reigning champions PSG take on two-time winners Chelsea
- *Real Madrid vs Manchester City*: Fifth consecutive knockout tie meeting between the teams
- *Newcastle United vs Barcelona*: Newcastle face Spanish champions Barcelona
- *Bodo/Glimt vs Sporting CP*: Norwegian upstarts Bodo/Glimt face Sporting CP
- *Galatasaray vs Liverpool*: Liverpool face Galatasaray in a league phase rematch
- *Atalanta vs Bayern Munich*: Italian side Atalanta take on German powerhouse Bayern
- *Atletico Madrid vs Tottenham Hotspur*: Tottenham face Atletico Madrid in a tough assignment
- *Bayer Leverkusen vs Arsenal*: Arsenal take on German side Bayer Leverkusen
The Champions League final will take place at the puskas Arena in Budapest on May 30, 2026.